Mass spectrometry and lipids

Mass Spectrometry and Lipids

Zora technology is based on more than a decade of mass spectrometry experience. Our mass spectrometry platforms are tailored to lipid analytics. We have successfully applied our analytical know-how to a range of proprietary studies with pharmaceutical companies and academic partners. Lipids have been analyzed in multitude of tissue and matrix types spanning indication areas from cardiovascular diseases, diabetes, central nervous system disorders, inflammation, oncology and hepatic diseases among other.

Lipids play key roles in all areas of cell biology such as energy storage, membrane structure and dynamics, signaling and regulation. Lipids are bioactive molecules and changes in lipid metabolism contribute to diverse phenotypes and disease states. Thus, lipidomic analyses provide valuable insight on the mechanisms and biological pathways of various conditions and are good target candidates for diagnostics and therapeutics.

Zora Mass Spectrometry laboratory is focused on high-throughput quantitative analyses using state-of-art instrumentation. Analytical setup includes 96-well format robotics for sample preparation and UHPLC-MS or direct infusion-MS and the latest linear ion trap mass spectrometers for high-throughput analysis of biological compounds for diagnostic IP discovery.

For more information, please refer to:

Kauhanen et al. 2016 Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides

Heiskanen et al. 2013 Long-term performance and stability of molecular shotgun lipidomic analysis of human plasma samples

Puri et al. 2016 Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese

Skorve et al. 2015 Fish oil and krill oil differentially modify the liver and brain lipidome when fed to mice

Marcher et al 2015 RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold