Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

Ruuth M. et al. 2018 European Heart Journal, 2018: 39 (27),2562–2573.

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Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients

Anroedh et al. 2018 The Journal of Lipid Research. June 1, 2018, doi: 10.1194/jlr.P081281

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Ceramide stearic to palmitic acid ratio predicts incident diabetes

Hilvo et al. Diabetologia (2018) 61: 1424. https://doi.org/10.1007/s00125-018-4590-6

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PCSK9 inhibition alters the lipidome of plasma and lipoprotein fractions

Hilvo et al. 2018 Atherosclerosis Volume 269, Pages 159–165

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High-grade ovarian serous carcinoma patients exhibit profound alterations in lipid metabolism

Braicu et al. Oncotarget. 2017; 8:102912-102922

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Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort

Havulinna et al. Arterioscler Thromb Vasc Biol. 2016; 36

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Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol

Laaksonen et al. European Heart Journal, Published online: 28 April 2016

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Accumulated Metabolites of Hydroxybutyric Acid Serve as Diagnostic and Prognostic Biomarkers of Ovarian High-Grade Serous Carcinomas

Hilvo et al. Cancer Res. 2016 Feb 15;76(4):796-804

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Lipidomics: a tool for studies of atherosclerosis

Ekroos K et al. Curr Atheroscler Rep. 2010 Jul;12(4):273-81

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Development and validation of a high-throughput LC-MS/MS assay for routine measurement of molecular ceramides

Kauhanen D et al. Anal Bioanal Chem. 2016 May;408(13):3475-83

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Lipidomics in drug discovery

Vihervaara T et al. Drug Discov Today 2014 Feb;19(2):164-70

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STOMPing forward: statins, muscle complaints and CK

Laaksonen R. Atherosclerosis. 2013 Oct;230(2):256-7

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Beyond LDL-C lowering: distinct molecular sphingolipids are good indicators of proprotein convertase subtilisin/kexin type 9 (PCSK9) deficiency

Jänis et al. Atherosclerosis 2013 Jun;228(2):380-5

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Identifying new Risk Markers and Potential Targets for Coronary Artery Disease: The Value of the Lipidome and Metabolome

Laaksonen R. Cardiovasc Drugs Ther. 2016 Feb;30(1):19-32

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Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study

Cheng JM et al. Atherosclerosis 2015 Dec;243(2):560-6.

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Molecular lipids identify cardiovascular risk and are efficiently lowered by simvastatin and PCSK9 deficiency

Tarasov K et al. J Clin Endocrinol Metab. 2014 Jan;99(1):E45-52

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Alcohol produces distinct hepatic lipidome and eicosanoid signature in lean and obese

Puri P et al. J Lipid Res. 2016 Mar 28

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Long-term performance and stability of molecular shotgun lipidomic analysis of human plasma samples

Heiskanen LA et al. Anal Chem. 2013 Sep 17;85(18):8757-63

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RNA-Seq and Mass-Spectrometry-Based Lipidomics Reveal Extensive Changes of Glycerolipid Pathways in Brown Adipose Tissue in Response to Cold

Marcher et al. Cell Rep. 2015 Dec 1;13(9):2000-13

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Fish oil and krill oil differentially modify the liver and brain lipidome when fed to mice.

Skorve J et al. Lipids Health Dis. 2015 Aug 11;14:88

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